The school started as a private institution known as Mamfe State College in 1984 with the following courses:
- General Arts
At the moment it is offering all courses with the exception of technical programmes:
- General Arts
- General Science
- General Agriculture
- Home Economics
- Visual Arts
In 1988 as a result of financial, administrative and staffing problems, the school was handed over to Methodist Church Ghana, Wesleyan Society, Mamfe-Akuapem as a private Methodist Secondary school. It was renamed Methodist High School, Mamfe and relocated at Mamfe Community Centre.
In January 1993, the school was absorbed by the Government into the public system.
In January, 2002 a new Headmistress was posted to the school. The school had a lot of challenges and a proposal was made to the stakeholders to support the distressed school and to convert it to purely girls’ school. The traditional council (Kyidomman Council) sent a proposal to Ghana Education Service and Methodist Church, Ghana to convert the school which already had a large population of girls in the Akuapem North District.
Approval was given for the school to be converted to a girls’ school in September, 2003. This was to be the first girls Senior High School in Akuapem North District.
The few boys were phased out gradually until September 2003 when the first batch of girls were admitted to the then SSS 1
Methodist High School had been a day school with hostel facilities since the school was absorbed into the public system in 1993.
In 2005/2006 academic year the school was given a boarding status. This together with the conversion of the school to a girls’ school, to a very large extent helped in increasing enrolment and saved the school from collapsing. Currently the school population stands at one thousand nine hundred and seventy-Eight (1,978).
The school is located at Mamfe-Akuapem at the highest habitable point on the Akuapem ridge to be precise.
The 40.2 acre land originally donated by the chiefs and people of Mamfe but now reduced to 36.2 acres due to activities of encroachers. The school is centrally placed and attracts both qualified tutors and students as well.